Exploring how tyrosine phosphorylation affects cell signaling and function
Systematic approaches to reveal novel regulatory functions of tyrosine phosphorylation
This study is looking at how a specific chemical change in proteins helps cells communicate and respond to signals from their environment, which could help us understand more about certain health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10884262 on NIH RePORTER |
What this research studies
This research investigates the role of tyrosine phosphorylation in cell signaling, which is crucial for how cells respond to external signals. By identifying and analyzing specific sites of tyrosine phosphorylation within protein domains, the project aims to understand how these modifications influence cellular processes and disease mechanisms. The approach combines computational methods with experimental techniques to uncover the regulatory functions of these phosphorylation sites, potentially leading to new insights into various health conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers or metabolic disorders like diabetes, where cell signaling plays a critical role.
Not a fit: Patients with conditions unrelated to cell signaling or tyrosine phosphorylation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to cell signaling dysfunction, including cancers and diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of phosphorylation in cell signaling, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Naegle, Kristen M — University of Virginia
- Study coordinator: Naegle, Kristen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.