Exploring how TRPV1, a pain-related ion channel, is activated by different stimuli.
Understanding human TRPV1 polymodal activation
['FUNDING_R01'] · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · NIH-11073035
This study is looking at a special part of our cells that helps us feel pain and temperature, to understand how it works when we experience things like heat or spicy foods, and the goal is to find new ways to create pain relief medicines that work better and have fewer side effects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARIZONA STATE UNIVERSITY-TEMPE CAMPUS (nih funded) |
| Locations | 1 site (TEMPE, UNITED STATES) |
| Trial ID | NIH-11073035 on ClinicalTrials.gov |
What this research studies
This research investigates the TRPV1 ion channel, which plays a crucial role in how our bodies perceive pain and temperature. By examining how TRPV1 is activated by various stimuli such as heat, acidity, and chemical compounds like capsaicin, the study aims to uncover the underlying mechanisms of its function. The research employs advanced techniques like nuclear magnetic resonance spectroscopy and electrophysiology to analyze the interactions and effects of different activation modes. The findings could lead to the development of better pain relief medications with fewer side effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic pain conditions or those who may benefit from new analgesic treatments.
Not a fit: Patients who do not experience pain or have conditions unrelated to TRPV1 activation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management therapies that minimize adverse effects on body temperature regulation.
How similar studies have performed: Previous research has shown promise in targeting TRPV1 for pain relief, indicating that this approach has potential for success.
Where this research is happening
TEMPE, UNITED STATES
- ARIZONA STATE UNIVERSITY-TEMPE CAMPUS — TEMPE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VAN HORN, WADE D. — ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- Study coordinator: VAN HORN, WADE D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.