Exploring how transposons create new immune gene variants
Official title: Understanding how transposons generate new immune gene protein-coding splice variants
Funded at University of Colorado · NIH-11031946 · Data updated 2026-11-12
This study is looking at how certain moving pieces of DNA, called transposons, help create new versions of immune genes that might improve our body's ability to fight off infections.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $125,000 |
| NIH project number | 5K99GM152820-02 |
| Project ID | NIH-11031946 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic variations that may affect their immune responses, particularly those involved in inflammatory diseases.
✕Less likely to help
Patients with stable immune conditions that do not involve genetic mutations or variations may not benefit from this research.
What this research studies
This research investigates the role of transposons, which are genetic elements that can move within the genome, in generating new protein-coding variants of immune genes. By focusing on a specific immune receptor gene, the project aims to understand how these transposon-derived variants contribute to the body's ability to adapt to pathogens. The approach involves analyzing genetic data and conducting experiments to uncover the mechanisms behind these variations and their potential functions in immune responses.
Why it matters
Potential benefit: If successful, this research could lead to new insights into immune system functioning and the development of novel therapeutic strategies for immune-related conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of transposons in gene expression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Pasquesi, Giulia Irene Maria — University of Colorado
- Study coordinator: Pasquesi, Giulia Irene Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.