Exploring how to improve immunity to poliovirus through vaccines and gut health.
Official title: Understanding the Development of Mucosal Immunity to Poliovirus: Adjuvants and Modulation of the Enteric Microbiota
Funded at University of Vermont & St Agric College · NIH-10983632 · Data updated 2026-11-12
This study is looking at ways to boost the body's defenses against poliovirus, especially after getting the oral vaccine, by examining past trial data and samples, and seeing how gut bacteria and a new helper can improve immune responses, all to help make vaccines more effective for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project start | July 26, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $161,616 |
| NIH project number | 1K23AI175660-01A1 |
| Project ID | NIH-10983632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are at risk of poliovirus infection or transmission.
✕Less likely to help
Patients who are not at risk of poliovirus or those who have already been vaccinated with effective vaccines may not benefit from this research.
What this research studies
This research investigates how to enhance mucosal immunity to poliovirus, which is crucial for preventing its transmission and eradication. The study will analyze existing data and biological samples from previous clinical trials to understand immune responses during oral poliovirus vaccination. It will also explore the effects of gut microbiota and a new mucosal adjuvant on immune responses. By identifying effective immune profiles, the research aims to improve vaccine strategies against poliovirus.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide better protection against poliovirus and reduce its transmission.
How similar studies have gone: Previous research has shown promise in enhancing mucosal immunity through vaccine strategies, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Vermont & St Agric College
Burlington, United States Active
Researchers
- Principal investigator: Crothers, Jessica W. — University of Vermont & St Agric College
- Study coordinator: Crothers, Jessica W.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.