Exploring how to enhance the effects of natural compounds that regulate pain and inflammation.

Modulating Signaling Endocannabinoids and Fatty Acid Amides

NIH-funded research Scripps Research Institute, the · NIH-10991676

This study is exploring how to better use natural compounds in your body that help with pain and inflammation, aiming to create safer and more effective treatments for chronic pain that don’t have the side effects of regular pain medications.

Quick facts

Grant typeR37 grant
Study typeNIH-funded research
Funding institutionScripps Research Institute, the NIH-funded
Lab location1 site (La Jolla, United States)
Project IDNIH-10991676 on NIH RePORTER

What this research studies

This research focuses on understanding and modulating the activity of endocannabinoids, which are natural compounds in the body that help regulate pain and inflammation. By targeting specific enzymes that control the release and breakdown of these compounds, the research aims to develop new therapeutic strategies that can provide pain relief without the side effects associated with traditional pain medications. Patients may benefit from a more effective and safer approach to managing chronic pain and related conditions. The research employs advanced biochemical techniques to investigate these mechanisms in detail.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals suffering from chronic pain or inflammatory conditions who are seeking alternative treatment options.

Not a fit: Patients who do not experience chronic pain or inflammatory conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new treatments for chronic pain that minimize side effects and improve patient outcomes.

How similar studies have performed: Previous research has shown promise in targeting the endocannabinoid system for pain management, indicating that this approach could be a viable therapeutic strategy.

Where this research is happening

La Jolla, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.