Exploring how tiny vesicles in the brain affect Alzheimer's disease
Official title: A new perspective on the role of extracellular vesicles in Alzheimer's disease
Funded at Nathan S. Kline Institute for Psych Res · NIH-10859331 · Data updated 2026-11-12
This study is looking at tiny particles called mitovesicles that might help clean up harmful materials in the brains of people with Alzheimer's disease, and it aims to find new ways to understand and treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nathan S. Kline Institute for Psych Res NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,413,601 |
| NIH project number | 1RF1AG086510-01 |
| Project ID | NIH-10859331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk for developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates the role of extracellular vesicles (EVs) in Alzheimer's disease, focusing on a newly discovered subtype called mitovesicles. These vesicles may help remove harmful materials from brain cells and could be involved in the spread of disease. The study will use both laboratory and animal models to understand how these vesicles are produced, how they function, and their impact on brain health. Patients may benefit from insights into new biomarkers and potential therapeutic targets for Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new ways to diagnose and treat Alzheimer's disease.
How similar studies have gone: While the investigation of extracellular vesicles is a growing field, the specific focus on mitovesicles in Alzheimer's disease is novel and has not been extensively tested.
Where this research is happening
-
Nathan S. Kline Institute for Psych Res
Orangeburg, United States Active
Researchers
- Principal investigator: Levy, Efrat — Nathan S. Kline Institute for Psych Res
- Study coordinator: Levy, Efrat
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.