Exploring how the spleen can influence a key protein in treating lupus
Official title: Splenic Modulation of SHP-2 Activity as a Therapeutic Option for Systemic Lupus Erythematosus
Funded at Masonic Medical Research Laboratory, INC · NIH-10788467 · Data updated 2026-11-12
This study is looking at how the spleen helps control a protein related to lupus, with the goal of finding new treatments that work better and have fewer side effects for people living with the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Masonic Medical Research Laboratory, INC NIH-funded |
| Lab location | 1 site (Utica, United States) |
| Project start | March 1, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $189,926 |
| NIH project number | 5R21AR081535-02 |
| Project ID | NIH-10788467 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus who are seeking new treatment options.
✕Less likely to help
Patients with other autoimmune disorders or those not diagnosed with systemic lupus erythematosus may not benefit from this research.
What this research studies
This research investigates the role of the spleen in regulating SHP-2 activity, a protein linked to the autoimmune disease systemic lupus erythematosus (SLE). By focusing on the spleen's unique immune functions, the study aims to develop targeted therapies that could minimize side effects compared to current treatments. The approach involves understanding how manipulating SHP-2 in the spleen can improve immune responses and potentially alleviate symptoms of SLE. Patients may be monitored for changes in disease activity and overall health as part of this innovative therapeutic strategy.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients with systemic lupus erythematosus.
How similar studies have gone: While the specific approach of targeting SHP-2 through splenic modulation is novel, similar strategies in autoimmune research have shown promise in other contexts.
Where this research is happening
-
Masonic Medical Research Laboratory, INC
Utica, United States Active
Researchers
- Principal investigator: Mccarthy, Jason R. — Masonic Medical Research Laboratory, INC
- Study coordinator: Mccarthy, Jason R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.