Exploring how the Mediterranean diet can lower colorectal cancer risk by affecting gut bacteria and bile acids.
Official title: Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer Risk
Funded at University of Illinois at Chicago · NIH-11003339 · Data updated 2026-11-12
This study is looking at how following a Mediterranean diet and losing weight can help lower the risk of colorectal cancer, especially for African Americans who are more at risk, by improving gut health and reducing harmful bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | January 15, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $616,177 |
| NIH project number | 5R01CA250390-05 |
| Project ID | NIH-11003339 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American adults who are at risk for colorectal cancer due to obesity and dietary habits.
✕Less likely to help
Patients who do not identify as African American or those who are not at risk for colorectal cancer may not benefit from this research.
What this research studies
This research investigates the relationship between the Mediterranean diet, weight loss, and colorectal cancer risk, particularly in African American populations who are at higher risk. The study focuses on how dietary changes can influence bile acids and gut microbiome composition, which are linked to cancer development. By promoting a plant-based diet and weight loss, the research aims to reduce harmful bacteria associated with colorectal cancer. Participants may be involved in dietary interventions and assessments to evaluate changes in their gut health and cancer risk.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that significantly lower the risk of colorectal cancer for at-risk populations.
How similar studies have gone: Previous research has shown promising results in using dietary interventions to modify gut microbiota and reduce cancer risk, suggesting that this approach may be effective.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Fitzgibbon, Marian L. — University of Illinois at Chicago
- Study coordinator: Fitzgibbon, Marian L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.