Exploring how the immune system recognizes and responds to Cryptosporidium infections
Official title: Understanding Innate Immune Recognition and IFN-g-Mediated Immunity in Cryptosporidiosis
Funded at University of Rochester · NIH-11092743 · Data updated 2026-11-12
This study is looking at how young children's immune systems fight off a parasite called Cryptosporidium, which causes an illness known as cryptosporidiosis, to help find ways to create better vaccines or treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 21, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $707,782 |
| NIH project number | 5R01AI184464-02 |
| Project ID | NIH-11092743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old, particularly those in developing regions who are at higher risk for cryptosporidiosis.
✕Less likely to help
Patients who are older than 11 years or those without a history of cryptosporidiosis may not benefit from this research.
What this research studies
This research investigates the immune response to Cryptosporidium, a parasite that causes cryptosporidiosis, particularly in young children. The team will use mouse models to study how the immune system detects the parasite and activates defenses, focusing on specific immune pathways. By understanding these mechanisms, the research aims to identify potential targets for developing vaccines or therapies to combat this disease. The findings could lead to improved strategies for preventing and treating cryptosporidiosis in vulnerable populations.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines or treatments for cryptosporidiosis, significantly improving health outcomes for affected children.
How similar studies have gone: Previous research has shown promise in understanding immune responses to similar parasitic infections, but this specific approach to cryptosporidiosis is relatively novel.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Yarovinsky, Felix — University of Rochester
- Study coordinator: Yarovinsky, Felix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.