Exploring how the immune system interacts with the brain after a traumatic injury
Understanding and Controlling Neuro-immune Interactions Following Traumatic Brain Injury
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10973775
This study is looking at how the immune system interacts with the brain after a traumatic brain injury to find ways to help reduce inflammation and improve recovery for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10973775 on ClinicalTrials.gov |
What this research studies
This research investigates the complex relationship between the immune system and the brain following a traumatic brain injury (TBI). It aims to understand how immune cells infiltrate the injured brain and contribute to inflammation and neurological deficits. By using a clinically relevant model, the study will quantify the timing and extent of immune cell infiltration and assess their functionality. The ultimate goal is to develop a therapeutic strategy that utilizes these immune cells to reduce neuroinflammation and improve recovery outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a traumatic brain injury.
Not a fit: Patients with chronic neurological conditions unrelated to traumatic brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce complications for individuals who have suffered a traumatic brain injury.
How similar studies have performed: While the interaction between the immune system and brain post-TBI is a relatively novel area of investigation, preliminary studies suggest that targeting neuroinflammation may improve outcomes in similar contexts.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOFFORD, KATHRYN LEIGH — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: WOFFORD, KATHRYN LEIGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury