Exploring how the human brain develops after birth using advanced cell models
Unlocking the postnatal human brain using activity augmented organoids
This study is looking at how the human brain grows after birth by using tiny brain models made from stem cells, which can help us understand brain development and related disorders better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10473206 on NIH RePORTER |
What this research studies
This research investigates the development of the human brain after birth by utilizing advanced three-dimensional brain cell cultures known as organoids. These organoids are created from human pluripotent stem cells and mimic the structure and function of the human brain, allowing researchers to study how brain cells proliferate and differentiate. The goal is to enhance the maturation of these organoids to better represent postnatal brain development, which has been challenging in previous studies. By improving these models, the research aims to provide insights into neurological disorders and brain development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders, particularly those related to brain development and function.
Not a fit: Patients with acute brain injuries or conditions that do not involve developmental aspects of the brain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for neurological disorders such as epilepsy.
How similar studies have performed: Previous research using brain organoids has shown promise in modeling prenatal brain development, but this approach to postnatal stages is relatively novel and untested.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Makinson, Christopher Donald — Columbia University Health Sciences
- Study coordinator: Makinson, Christopher Donald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.