Exploring how the gut environment and genetics influence the development of colon polyps
Understanding adenoma progression: Interplay among tissue microenvironment, clonal architecture, and gut microbiome
This study is looking at how certain growths in the colon, called adenomas, can turn into cancer, and it's for anyone interested in understanding why some of these growths become more serious while others don’t, with the hope of finding ways to prevent colorectal cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11014909 on NIH RePORTER |
What this research studies
This research investigates the progression of colon adenomas, which are precursors to colorectal cancer, by examining the interplay between the tissue microenvironment, genetic factors, and gut microbiome. The study aims to identify the mechanisms that lead to the transformation of early adenomas into advanced adenomas and ultimately colorectal cancer. By analyzing various biological markers and patterns of DNA methylation, researchers hope to uncover why only some adenomas progress while others do not. This could lead to better understanding and prevention strategies for colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diagnosed colon adenomas or those at risk for colorectal cancer.
Not a fit: Patients who do not have any history of colon adenomas or colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing colorectal cancer by identifying individuals at higher risk based on their adenoma characteristics.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of adenoma progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Grady, William Mallory — Fred Hutchinson Cancer Center
- Study coordinator: Grady, William Mallory
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.