Exploring how the Fragile X protein helps maintain DNA stability
Understanding the Genome Maintenance Function of the Fragile X Protein (FMRP)
This study is looking at how a protein called FMRP helps keep DNA safe in people with Fragile X syndrome, especially during tough times when DNA can get damaged, and it hopes to find new ways to understand and treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10661830 on NIH RePORTER |
What this research studies
This research investigates the role of the Fragile X protein (FMRP) in maintaining the stability of DNA within cells, particularly in individuals with Fragile X syndrome (FXS). The study focuses on how FMRP prevents DNA damage during stressful conditions that can lead to genetic instability. By examining the interactions between FMRP and specific DNA structures, the research aims to uncover new mechanisms that could explain the genetic issues associated with FXS. Patients may benefit from insights gained about the underlying causes of their condition and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X syndrome or those carrying mutations in the FMR1 gene.
Not a fit: Patients without Fragile X syndrome or related genetic conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Fragile X syndrome.
How similar studies have performed: Previous research has shown promising results in understanding the genetic mechanisms of Fragile X syndrome, but this specific approach to studying FMRP's nuclear functions is relatively novel.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Feng, Wenyi — Upstate Medical University
- Study coordinator: Feng, Wenyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.