Exploring how the BCG vaccine boosts immune memory in newborns
Official title: Immunometabolic signatures of BCG-induced neonatal trained immunity
Funded at Beth Israel Deaconess Medical Center · NIH-10883577 · Data updated 2026-11-12
This study is looking at how the BCG vaccine might help newborns' immune systems remember infections better, which could keep them healthier in the long run, and it's being led by a pediatric expert to make sure the findings are reliable and useful for babies who need extra protection.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 6, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $175,572 |
| NIH project number | 5K08AI168487-02 |
| Project ID | NIH-10883577 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns aged 0-4 weeks who receive the BCG vaccine.
✕Less likely to help
Patients who are older than 4 weeks or those who have not received the BCG vaccine may not benefit from this research.
What this research studies
This research investigates the BCG vaccine's ability to enhance the immune system's memory in newborns, potentially leading to better protection against infections. The study focuses on understanding the biological mechanisms behind this 'trained immunity' and how it can provide long-lasting health benefits. By analyzing immune responses in infants, the research aims to uncover new insights that could improve vaccination strategies and outcomes for vulnerable populations. The project is led by a pediatric expert at a prominent medical center, ensuring a high level of scientific rigor and clinical relevance.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies that enhance the immune protection of newborns against various infections.
How similar studies have gone: Previous research has shown promising results in understanding the effects of the BCG vaccine on immune responses, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Angelidou, Asimenia — Beth Israel Deaconess Medical Center
- Study coordinator: Angelidou, Asimenia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.