Exploring how the 3D structure of DNA affects cell function and disease
Official title: Development of multi-color 3D super-localization LiveFISH and LiveFISH PAINT to investigate the chromatin dynamics at any genomic scale
Funded at Stanford University · NIH-10725002 · Data updated 2026-11-12
This study is exploring how the way DNA is organized in our cells affects how genes work and how cells behave, using new imaging techniques to see these changes in real-time, which could help us understand diseases like cancer better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $420,379 |
| NIH project number | 1R21HG013133-01 |
| Project ID | NIH-10725002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or other diseases linked to chromatin organization and gene expression.
✕Less likely to help
Patients with conditions unrelated to chromatin dynamics or those not eligible for advanced imaging techniques may not benefit from this research.
What this research studies
This research focuses on understanding the three-dimensional organization of DNA within cells and how it influences gene expression and cellular behavior. By developing advanced imaging techniques, the study aims to visualize the dynamic changes in chromatin structure in real-time, which is crucial for understanding various diseases, including cancers. The approach utilizes CRISPR technology to label specific DNA regions in live cells, allowing researchers to track changes over time without the need for extensive cell line development. This innovative method could provide insights into the relationship between chromatin organization and cellular function.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases related to chromatin dysfunction, particularly cancers.
How similar studies have gone: Previous research using CRISPR-based imaging techniques has shown promise in understanding chromatin dynamics, indicating potential for success in this novel approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Qi, Lei Stanley — Stanford University
- Study coordinator: Qi, Lei Stanley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.