Exploring how the 3D structure of DNA affects cell function and disease
Development of multi-color 3D super-localization LiveFISH and LiveFISH PAINT to investigate the chromatin dynamics at any genomic scale
['FUNDING_R21'] · STANFORD UNIVERSITY · NIH-10725002
This study is exploring how the way DNA is organized in our cells affects how genes work and how cells behave, using new imaging techniques to see these changes in real-time, which could help us understand diseases like cancer better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10725002 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the three-dimensional organization of DNA within cells and how it influences gene expression and cellular behavior. By developing advanced imaging techniques, the study aims to visualize the dynamic changes in chromatin structure in real-time, which is crucial for understanding various diseases, including cancers. The approach utilizes CRISPR technology to label specific DNA regions in live cells, allowing researchers to track changes over time without the need for extensive cell line development. This innovative method could provide insights into the relationship between chromatin organization and cellular function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or other diseases linked to chromatin organization and gene expression.
Not a fit: Patients with conditions unrelated to chromatin dynamics or those not eligible for advanced imaging techniques may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases related to chromatin dysfunction, particularly cancers.
How similar studies have performed: Previous research using CRISPR-based imaging techniques has shown promise in understanding chromatin dynamics, indicating potential for success in this novel approach.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QI, LEI STANLEY — STANFORD UNIVERSITY
- Study coordinator: QI, LEI STANLEY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer