Exploring how THC affects pain signaling in the brain
Official title: Investigating the role of THC in mediating pain signaling in the BLA
Funded at University of Washington · NIH-10995720 · Data updated 2026-11-12
This study is looking at how THC, a natural compound in cannabis, might help reduce pain by affecting a part of the brain that deals with both pain and emotions, and it's aimed at people who are dealing with chronic pain and want safer alternatives to opioids.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $45,685 |
| NIH project number | 1F31DA061576-01 |
| Project ID | NIH-10995720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic pain who may benefit from alternative pain relief methods.
✕Less likely to help
Patients who do not experience chronic pain or those who are not interested in cannabis-based treatments may not benefit from this research.
What this research studies
This research investigates the effects of Δ9-tetrahydrocannabinol (THC), a compound found in cannabis, on pain signaling in the basolateral amygdala (BLA), a brain region involved in processing pain and emotions. The study aims to understand the mechanisms by which THC may reduce pain by acting on specific receptors in the brain. By examining the neuronal activity in the BLA during chronic pain, the research seeks to uncover how THC can potentially provide relief without the high risk of addiction associated with traditional opioid medications.
Why it matters
Potential benefit: If successful, this research could lead to new, safer pain management options for patients suffering from chronic pain.
How similar studies have gone: Previous research has shown promising results in using THC for pain relief, indicating that this approach may lead to significant advancements in pain management.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Ellioff, Kaylin — University of Washington
- Study coordinator: Ellioff, Kaylin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.