Exploring how terpenes can reduce pain sensitivity through the endocannabinoid system
Official title: Modulation of pain hypersensitivity by terpenes via endocannabinoid release in descending circuits
Funded at University of California Los Angeles · NIH-10903357 · Data updated 2026-11-12
This study is looking at how natural compounds from cannabis, called terpenes, might help reduce pain sensitivity by affecting the brain's pain control system, and it's aimed at finding new ways to help people manage chronic pain.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $44,671 |
| NIH project number | 1F31AT012836-01 |
| Project ID | NIH-10903357 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who suffer from chronic pain conditions.
✕Less likely to help
Patients who do not experience chronic pain or are under 21 years old may not benefit from this research.
What this research studies
This research investigates the potential of terpenes, natural compounds found in cannabis, to modulate pain hypersensitivity by influencing the endocannabinoid system. The study aims to understand how terpenes can alter endocannabinoid levels in the brain's pain modulation circuits, particularly in the ventrolateral periaqueductal gray (vlPAG) region. By utilizing a novel modified sensor for cannabinoid receptors, the research will explore the mechanisms behind the analgesic effects of terpenes, which may provide new therapeutic options for chronic pain management.
Why it matters
Potential benefit: If successful, this research could lead to new, safer pain management therapies that reduce reliance on opioids.
How similar studies have gone: Previous research has shown promising results in using cannabis and its components for pain relief, indicating potential success for this novel approach.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Rice, Myra Jane — University of California Los Angeles
- Study coordinator: Rice, Myra Jane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.