Exploring how temperature affects tau protein buildup in early Alzheimer's disease
Investigating the Temperature Dependence of Age-related Tau Pathology Relevant to Early Alzheimer's Disease
This study is looking at how body temperature might affect the buildup of tau protein in the brains of older adults, which is important for understanding early Alzheimer's disease, and it's designed for older people who may be at risk for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11080866 on NIH RePORTER |
What this research studies
This research investigates the relationship between body temperature and the accumulation of tau protein tangles in the brains of older adults, which is a key feature of early Alzheimer's disease. By measuring body temperature and using advanced imaging techniques, the study aims to understand how lower temperatures may influence the development of tau pathology. The research builds on previous findings in animal models and seeks to translate these insights into human subjects, particularly focusing on older individuals who may be at risk for Alzheimer's. Participants will be monitored for temperature changes and their correlation with tau levels over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who may be experiencing early signs of Alzheimer's disease.
Not a fit: Patients who are younger than 65 or those who do not have any signs of cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease in older adults.
How similar studies have performed: Previous research has shown promising results in animal models regarding the impact of temperature on tau pathology, but this study aims to explore these findings in humans for the first time.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Blessing, Esther Marian — New York University School of Medicine
- Study coordinator: Blessing, Esther Marian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.