Exploring how tau protein affects young-onset Alzheimer's disease
Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's disease
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-10982511
This study is looking at how young-onset Alzheimer's disease affects the brains of people under 65, focusing on a protein called tau that may cause memory and thinking problems, with the hope of finding better ways to help younger patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-10982511 on ClinicalTrials.gov |
What this research studies
This research investigates the unique vulnerabilities of the brain in individuals diagnosed with young-onset Alzheimer's disease (YOAD), which occurs before the age of 65. By examining the accumulation of tau protein in specific brain regions, the study aims to understand how this accumulation leads to cognitive decline and atypical symptoms in younger patients. The researchers will utilize advanced neuroimaging techniques and neuropathological assessments to identify patterns of tau pathology and its impact on brain function. The findings could provide insights into targeted interventions for this specific age group.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with young-onset Alzheimer's disease who are under 65 years of age and do not have known genetic mutations associated with Alzheimer's.
Not a fit: Patients diagnosed with late-onset Alzheimer's disease or those with genetic mutations linked to Alzheimer's pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for young-onset Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding tau pathology in Alzheimer's disease, but this specific focus on young-onset cases is relatively novel.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MURRAY, MELISSA ERIN — MAYO CLINIC JACKSONVILLE
- Study coordinator: MURRAY, MELISSA ERIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.