Exploring how targeted brain stimulation can improve symptoms in mental health disorders
Probing the Functional and Behavioral Impact of Precision Circuit Modulation in Neuropsychiatric Disorders
This study is looking at how a special treatment called rTMS can help improve brain function in people with depression by using advanced imaging to see how their brain networks work, so we can tailor the treatment to better fit each person's needs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10873345 on NIH RePORTER |
What this research studies
This research investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on specific brain circuits associated with mental health disorders, particularly Major Depressive Disorder. By using advanced MRI techniques, the study aims to identify how different brain networks function in both healthy individuals and those with depression. Patients will receive targeted rTMS treatments on different days, allowing researchers to measure changes in brain activity and connectivity after each session. This approach seeks to personalize treatment by focusing on the specific circuits that contribute to individual symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Major Depressive Disorder who are seeking alternative treatment options.
Not a fit: Patients with neuropsychiatric disorders that do not respond to rTMS or those with contraindications for MRI may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments for patients suffering from neuropsychiatric disorders.
How similar studies have performed: Previous research has shown promising results using rTMS for treating depression, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Eldaief, Mark Christian — Massachusetts General Hospital
- Study coordinator: Eldaief, Mark Christian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.