Exploring how supercoiling affects DNA activity and drug interactions
Harnessing Supercoiling to Regulate DNA Activity
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-10911162
This study is looking at how DNA twists and interacts with important proteins that help it work properly, which could lead to better treatments for infections and cancer, and help improve gene therapy for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10911162 on ClinicalTrials.gov |
What this research studies
This research investigates the role of supercoiling in DNA and its interactions with topoisomerases, which are crucial for DNA function and targeted by various drugs. By using advanced techniques like electron cryo-microscopy, the researchers aim to visualize the 3-D structure of these proteins bound to DNA. The study also explores how engineered DNA minicircles can be used in gene therapy and how supercoiling influences the effectiveness of antimicrobial and anticancer agents. Patients may benefit from insights gained about drug interactions and potential new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with cancers or infections that are treated with topoisomerase-targeting drugs.
Not a fit: Patients with conditions unrelated to DNA supercoiling or those not treated with topoisomerase inhibitors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancers and infections by enhancing the effectiveness of existing drugs.
How similar studies have performed: Previous research has shown promising results in understanding DNA interactions and drug efficacy, indicating that this approach has potential for success.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZECHIEDRICH, LYNN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: ZECHIEDRICH, LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents