Exploring how STING activation affects pancreatic cancer treatment
Leveraging Vulnerabilities Induced by STING Activation in Pancreatic Cancer
This study is looking at how activating a specific protein called STING might help slow down pancreatic cancer growth and improve treatment options for patients with this tough-to-treat disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11012779 on NIH RePORTER |
What this research studies
This research investigates the role of STING activation in pancreatic cancer, focusing on how it influences tumor growth and metabolism. By activating STING, the study aims to understand its effects on immune signaling and the biochemical processes within cancer cells. The researchers will analyze how these changes can be leveraged to improve treatment outcomes for patients with pancreatic ductal adenocarcinoma, a particularly aggressive form of cancer. The approach includes examining the impact of STING on nucleotide metabolism and DNA replication stress responses in cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are seeking innovative treatment options.
Not a fit: Patients with other types of cancer or those who do not have pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the effectiveness of treatments for pancreatic cancer.
How similar studies have performed: Other research has shown promising results with STING activation in cancer therapy, indicating potential for success in this approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Donahue, Timothy R — University of California Los Angeles
- Study coordinator: Donahue, Timothy R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.