Exploring how specific proteins in brain cells relate to Alzheimer's disease
Activity-dependent probes for spatially-defined proteomics
This study is exploring how certain brain cells work when they're active, using new tools to better understand the proteins involved, which could help us learn more about conditions like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10686705 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular properties of specific groups of neurons in the brain that are activated during certain functions. By developing new technologies, the researchers aim to tag and enrich proteins in these activated neurons, allowing for a better understanding of how these proteins contribute to brain function and behavior. This approach goes beyond traditional methods by linking protein expression directly to neural activity, which is crucial for understanding diseases like Alzheimer's. The research will involve high-throughput screening in cultured cells and testing in mouse brains to refine these new molecular tools.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurological conditions or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of Alzheimer's disease, potentially paving the way for innovative treatments.
How similar studies have performed: While the approach of linking protein expression to neural function is innovative, similar methodologies have shown promise in other areas of neuroscience.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Kim, Christina — University of California at Davis
- Study coordinator: Kim, Christina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.