Exploring how specific genes affect Alzheimer's disease and brain signaling.
UNDERSTANDING THE ROLE OF TM2D FAMILY GENES IN NOTCH SIGNALING AND ALZHEIMER'S DISEASE
This study is looking at how certain genes might affect the risk of developing Alzheimer's disease by using fruit flies to learn more about a key protein in the brain, and it aims to find new ways to help people with the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11077858 on NIH RePORTER |
What this research studies
This research investigates the role of TM2D family genes in the development of Alzheimer's disease (AD) by examining their impact on a critical protein involved in brain signaling. Using fruit flies as a model organism, the study aims to uncover how genetic variations in these genes contribute to the risk of developing late-onset AD. By understanding the molecular mechanisms at play, researchers hope to identify potential targets for therapeutic intervention. The collaboration with the CHARGE consortium enhances the study's depth by integrating genetic data from diverse populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are at risk for or diagnosed with Alzheimer's disease.
Not a fit: Patients with early-onset Alzheimer's disease or those without genetic risk factors for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and potential therapeutic targets, improving treatment options for patients.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Yamamoto, Shinya — Baylor College of Medicine
- Study coordinator: Yamamoto, Shinya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.