Exploring how special viruses can fight antibiotic-resistant infections caused by Pseudomonas aeruginosa.
Official title: Investigating the mechanism of infection and therapeutic potential of Pseudomonas nucleus-forming phages
Funded at University of California, San Diego · NIH-11004254 · Data updated 2026-11-12
This study is looking at a new kind of virus that might help treat infections caused by a tough bacteria called Pseudomonas aeruginosa, which often doesn't respond to antibiotics, to find better ways to help people who are dealing with these infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | December 6, 2023 |
| Project end | December 5, 2027 |
| Funding year | 2025 |
| Award (this year) | $42,100 |
| NIH project number | 5F30AI176696-02 |
| Project ID | NIH-11004254 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by Pseudomonas aeruginosa, particularly those with antibiotic-resistant strains.
✕Less likely to help
Patients with infections caused by bacteria other than Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research investigates a new type of virus called nucleus-forming bacteriophages that may offer a novel treatment for infections caused by Pseudomonas aeruginosa, a common and often antibiotic-resistant bacterium. The study aims to understand how these phages protect their genetic material and selectively transport proteins, which could enhance their effectiveness against bacterial infections. By examining the structure and function of specific proteins involved in this process, the research seeks to uncover mechanisms that could lead to improved therapies for patients suffering from these challenging infections.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients with antibiotic-resistant infections, potentially improving treatment outcomes.
How similar studies have gone: Previous research has shown promise in using bacteriophages as treatments for bacterial infections, indicating that this approach may be viable.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Morgan, Chase — University of California, San Diego
- Study coordinator: Morgan, Chase
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.