Exploring how social rewards can help treat depression in older adults

Positive valence systems engagement during social reward exposure psychotherapy for mid- and late-life depression

NIH-funded research Weill Medical Coll of Cornell Univ · NIH-10883686

This study is exploring a new type of therapy called 'Engage' that helps older adults with depression by encouraging social interactions and positive experiences, and it uses brain scans to see how these activities can improve mood and brain function.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionWeill Medical Coll of Cornell Univ NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-10883686 on NIH RePORTER

What this research studies

This research focuses on developing personalized psychotherapy techniques for mid- and late-life depression by engaging specific behavioral and neural targets. The approach involves a therapy called 'Engage,' which emphasizes social interactions and reward exposure to enhance emotional well-being. By using functional MRI, the study aims to identify how these social rewards can improve brain connectivity and behavioral activation, potentially leading to better treatment outcomes for older adults suffering from depression.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults experiencing mid- to late-life depression who may benefit from innovative psychotherapy approaches.

Not a fit: Patients with depression not related to social interactions or those who do not respond to psychotherapy may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective and personalized treatments for depression in older adults, improving their quality of life.

How similar studies have performed: Preliminary studies have shown promising results with similar approaches, indicating potential for success in this area.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.