Exploring how small RNA molecules regulate gene expression in cells
Official title: Understanding what regulates a regulator: the molecular basis for homeostatic small RNA-mediated gene regulation
Funded at University of Texas Arlington · NIH-11143233 · Data updated 2026-11-12
This study is looking at how tiny molecules in our cells help control genes, which could help us understand more about genetic diseases and cancer, so patients can learn how these processes might affect their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $373,397 |
| NIH project number | 5R35GM155429-02 |
| Project ID | NIH-11143233 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic disorders, cancers, or conditions related to mis-regulated gene expression.
✕Less likely to help
Patients with conditions unrelated to RNA interference or gene regulation may not receive any benefit from this research.
What this research studies
This research investigates the role of RNA interference (RNAi) pathways, which are essential for regulating gene expression in cells. By studying how small RNA molecules interact with Argonaute proteins, the research aims to understand the mechanisms that maintain balance in gene regulation. The approach involves creating novel mutants to observe the effects of disrupting RNAi homeostasis, which could reveal insights into genetic diseases, cancer, and other health issues. Patients may benefit from a deeper understanding of how gene regulation impacts their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating genetic diseases and cancers by restoring proper gene regulation.
How similar studies have gone: Previous research has shown promising results in understanding RNAi pathways, indicating that this approach could lead to significant advancements in gene regulation therapies.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Rogers, Alicia Kathryn — University of Texas Arlington
- Study coordinator: Rogers, Alicia Kathryn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.