Exploring how sleep issues affect inflammation and heart-related diseases.
Official title: Triangulating causal effects of sleep, inflammation, and cardiometabolic disease
Funded at Univ of North Carolina Chapel Hill · NIH-11066931 · Data updated 2026-11-12
This study is looking at how sleep issues, like insomnia and sleep apnea, might be linked to inflammation and heart-related health problems, and it aims to find new ways to help people feel better by focusing on certain molecules in the body.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | May 1, 2025 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $41,136 |
| NIH project number | 1F31HL177899-01 |
| Project ID | NIH-11066931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who experience sleep problems and may be at risk for cardiometabolic diseases.
✕Less likely to help
Patients who do not have sleep issues or existing cardiometabolic diseases may not benefit from this research.
What this research studies
This research investigates the connections between sleep problems, inflammation, and cardiometabolic diseases (CMDs) in individuals, particularly focusing on the role of specific molecules called oxylipins. By examining how sleep disorders like insomnia and sleep apnea relate to inflammation and CMDs, the study aims to identify potential pathways that could lead to better treatments. The research will involve a diverse group of participants to ensure comprehensive findings and will utilize advanced statistical models to analyze the data. Patients may be asked to provide information about their sleep patterns and health conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from sleep disorders and related cardiometabolic diseases.
How similar studies have gone: While some studies have explored the relationship between sleep and inflammation, this research aims to provide novel insights by focusing on specific oxylipins and their causal effects, making it a unique approach.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Koenigsberg, Sarah H. — Univ of North Carolina Chapel Hill
- Study coordinator: Koenigsberg, Sarah H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.