Exploring how sleep and physical activity affect brain health in aging and Alzheimer's disease
Insights into Cognitive Resilience: Sleep, Physical Activity, and Neuroimaging Biomarkers in Aging and Preclinical Alzheimer's Disease
This study is looking at how things like sleep and exercise can affect brain health in older adults and those at risk for Alzheimer's, to see if making changes in these areas can help keep their minds sharp as they age.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11108621 on NIH RePORTER |
What this research studies
This research investigates how lifestyle factors like sleep and physical activity can influence cognitive resilience in older adults and those at risk for Alzheimer's disease. By using actigraphy to monitor physical activity and sleep patterns, along with advanced neuroimaging techniques, the study aims to uncover the relationships between these factors and brain health over time. Participants will be monitored longitudinally to assess how changes in their activity and sleep may correlate with cognitive function and brain structure. The goal is to identify modifiable factors that could help maintain cognitive health as people age.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults and individuals showing early signs of Alzheimer's disease or related dementias.
Not a fit: Patients with advanced Alzheimer's disease or other severe cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cognitive resilience and delaying the onset of Alzheimer's disease symptoms.
How similar studies have performed: Previous research has shown promising results in understanding the impact of lifestyle factors on cognitive health, making this approach both relevant and potentially impactful.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Callow, Daniel — Johns Hopkins University
- Study coordinator: Callow, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.