NIH-funded research Career grant

Exploring how sleep and physical activity affect brain health in aging and Alzheimer's disease

Official title: Insights into Cognitive Resilience: Sleep, Physical Activity, and Neuroimaging Biomarkers in Aging and Preclinical Alzheimer's Disease

Funded at Johns Hopkins University · NIH-11108621 · Data updated 2026-11-12

This study is looking at how things like sleep and exercise can affect brain health in older adults and those at risk for Alzheimer's, to see if making changes in these areas can help keep their minds sharp as they age.

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Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionJohns Hopkins University
NIH-funded
Lab location1 site (Baltimore, United States)
Project startJune 15, 2025
Project endMarch 31, 2030
Funding year2025
Award (this year)$129,659
NIH project number1K01AG092954-01
Project IDNIH-11108621 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include older adults and individuals showing early signs of Alzheimer's disease or related dementias.

Less likely to help

Patients with advanced Alzheimer's disease or other severe cognitive impairments may not benefit from this research.

What this research studies

This research investigates how lifestyle factors like sleep and physical activity can influence cognitive resilience in older adults and those at risk for Alzheimer's disease. By using actigraphy to monitor physical activity and sleep patterns, along with advanced neuroimaging techniques, the study aims to uncover the relationships between these factors and brain health over time. Participants will be monitored longitudinally to assess how changes in their activity and sleep may correlate with cognitive function and brain structure. The goal is to identify modifiable factors that could help maintain cognitive health as people age.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for enhancing cognitive resilience and delaying the onset of Alzheimer's disease symptoms.

How similar studies have gone: Previous research has shown promising results in understanding the impact of lifestyle factors on cognitive health, making this approach both relevant and potentially impactful.

Where this research is happening

  • Johns Hopkins University
    Baltimore, United States
    Active

Researchers

  • Principal investigator: Callow, Daniel — Johns Hopkins University
  • Study coordinator: Callow, Daniel

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.