Exploring how sleep and Alzheimer's disease affect each other in the brain
Bidirectional interactions between sleep and Alzheimer's disease: Functional dissection of the brain transcriptome in humans and Drosophila
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11078823
This study is looking at how sleep problems might be connected to Alzheimer's disease in older adults, using both human brain samples and fruit flies to find out what happens in the brain, with the hope of discovering new ways to help people with these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11078823 on ClinicalTrials.gov |
What this research studies
This research investigates the complex relationship between sleep disturbances and Alzheimer's disease in older adults. It aims to uncover the molecular mechanisms in the brain that link these two conditions, using a unique approach that combines human brain analysis with genetic studies in fruit flies. By examining gene expression patterns associated with sleep disruption and Alzheimer's pathology, the study seeks to identify potential targets for intervention. The findings could help clarify how sleep issues may contribute to the development of Alzheimer's and vice versa.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing sleep problems and at risk for Alzheimer's disease.
Not a fit: Patients who do not have sleep disturbances or are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by addressing sleep disturbances.
How similar studies have performed: Previous studies have shown promising results in understanding the relationship between sleep and Alzheimer's, indicating that this research builds on established findings.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAW, PAUL J — WASHINGTON UNIVERSITY
- Study coordinator: SHAW, PAUL J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.