Exploring how sleep affects cognition and Alzheimer's disease biomarkers over time
Longitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and Susceptibility
This study is looking at how sleep problems might affect thinking skills and the risk of Alzheimer's disease, and it's for people who want to understand how their sleep and health are connected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10800699 on NIH RePORTER |
What this research studies
This research investigates the complex relationships between sleep patterns, cognitive function, and biomarkers associated with Alzheimer's disease. By analyzing data collected from participants over several years, the study aims to determine whether sleep disturbances contribute to cognitive decline and how factors like nocturnal hypertension may play a role. Participants will undergo comprehensive assessments, including cognitive tests and brain imaging, to understand these dynamics better. The goal is to identify potential interventions that could mitigate the risk of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing sleep disturbances or cognitive decline.
Not a fit: Patients with stable cognitive function and no sleep issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying cognitive decline in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the links between sleep and cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Redline, Susan S. — Brigham and Women's Hospital
- Study coordinator: Redline, Susan S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.