Exploring how signals from the exocrine pancreas can help beta cells grow
Official title: Understanding how exocrine-derived signals promote beta cell growth
Funded at Indiana University Indianapolis · NIH-11000764 · Data updated 2026-11-12
This study is looking at how different parts of the pancreas work together to help grow insulin-producing cells, which is important for keeping your blood sugar levels balanced.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $40,648 |
| NIH project number | 5F31DK137482-02 |
| Project ID | NIH-11000764 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who may have conditions affecting the pancreas, such as pancreatitis or exocrine insufficiency.
✕Less likely to help
Patients with no pancreatic issues or those who are not affected by conditions related to exocrine function may not benefit from this research.
What this research studies
This research investigates the relationship between the exocrine and endocrine parts of the pancreas, focusing on how signals from the exocrine pancreas can promote the growth of insulin-producing beta cells. The study aims to understand the molecular pathways involved in this communication, particularly the role of hypusine biosynthesis in cell growth. By examining these interactions, the research seeks to uncover potential mechanisms that could support beta cell function and growth, which is crucial for maintaining metabolic balance in the body.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing beta cell growth, potentially benefiting individuals with diabetes.
How similar studies have gone: Previous studies have shown promising results in understanding the interactions between the exocrine and endocrine pancreas, suggesting that this research builds on established findings.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Overton, Danielle Louisia — Indiana University Indianapolis
- Study coordinator: Overton, Danielle Louisia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.