Exploring how sex differences in immune cells affect chronic muscle pain
Identification of Sex Differences in Monocytes and Metabolism in the Maintenance of Chronic Muscle Pain
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10973685
This study is looking at how differences between men and women in certain immune cells might affect chronic muscle pain, especially in women with conditions like fibromyalgia, to help find better treatments for managing that pain.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10973685 on ClinicalTrials.gov |
What this research studies
This research investigates the role of sex differences in monocytes, a type of immune cell, and their metabolism in relation to chronic muscle pain, particularly in women who are disproportionately affected by conditions like fibromyalgia. Using a mouse model, the study will manipulate the metabolism of these immune cells to understand how it influences pain processing and inflammation. By examining pain behaviors and cellular responses, the research aims to uncover mechanisms that could lead to more effective, targeted treatments for chronic muscle pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals, especially women, who experience chronic muscle pain or fibromyalgia.
Not a fit: Patients with acute muscle pain or those not experiencing chronic pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that are more effective for individuals suffering from chronic muscle pain, particularly women.
How similar studies have performed: While there has been some research on sex differences in pain mechanisms, this specific approach focusing on monocyte metabolism in chronic muscle pain is relatively novel.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LENERT, MELISSA ELIZABETH — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: LENERT, MELISSA ELIZABETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.