NIH-funded research R15 grant

Exploring how sex differences and gut bacteria affect eating behaviors

Official title: Sex differences in hedonic feeding: the role of the gut microbiome

Funded at Furman University · NIH-10653326 · Data updated 2026-11-12

This study is looking at how the bacteria in our gut might affect why we eat certain foods for pleasure, especially tasty, high-fat ones, and it wants to see if there are differences between men and women in these eating habits, particularly to help understand obesity in women.

Quick facts

Grant typeR15 grant
Study typeNIH-funded research
Funding institutionFurman University
NIH-funded
Lab location1 site (Greenville, United States)
Project startSeptember 1, 2023
Project endAugust 31, 2026
Funding year2023
Award (this year)$416,456
NIH project number1R15DK136098-01
Project IDNIH-10653326 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adults, especially women, who are interested in understanding the factors influencing their eating behaviors and obesity risk.

Less likely to help

Patients who are not affected by obesity or do not have an interest in dietary behaviors may not benefit from this research.

What this research studies

This research investigates how the gut microbiome influences eating behaviors, particularly hedonic feeding, which is eating for pleasure rather than hunger. It focuses on understanding the differences between males and females in their food intake patterns, especially regarding high-fat, palatable foods. By analyzing fecal microbiome diversity, the study aims to uncover the biological factors that contribute to obesity, particularly in women. The research employs a combination of dietary assessments and microbiome analysis to explore these connections.

Why it matters

Potential benefit: If successful, this research could lead to new strategies for preventing and treating obesity, particularly among women.

How similar studies have gone: Previous research has shown promising results in understanding the relationship between the gut microbiome and eating behaviors, suggesting that this approach could yield valuable insights.

Where this research is happening

  • Furman University
    Greenville, United States
    Active

Researchers

  • Principal investigator: Freeman, Linnea Ruth — Furman University
  • Study coordinator: Freeman, Linnea Ruth

Related research

Other NIH-funded projects on the same topics.

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  • Aflatoxin exposure and child growth in Guatemala

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  • Gut bacteria that can make cancer immunotherapy less effective

    This project will see if reducing chronic inflammation driven by certain gut bacteria can help immunotherapy work better for people whose cancers have stopped responding.

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  • How gut bacteria affect how cancer drugs work

    This project looks at how the bacteria in your gut might change how well and with what side effects fluoropyrimidine cancer drugs like 5-FU work in people.

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  • Gut bacteria and cancer drugs: how your gut may change chemotherapy effectiveness

    This project studies how the gut microbiome might affect how well certain chemotherapy drugs work and their side effects in people with cancer.

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About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.