Exploring how sex and a specific gene affect Alzheimer's disease at the cellular level
Dissect the interplay between sex and APOE at the single cell level to uncover novel pathways, targets and therapeutics for Alzheimer's disease
This study is looking at how being male or female and a specific gene called APOE4 might affect the way Alzheimer's disease develops in the brain, with the goal of finding new ways to diagnose and treat the disease for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10892762 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between sex and the APOE4 gene, a known risk factor for Alzheimer's disease (AD), by analyzing single cells in the brain. It aims to uncover how these factors contribute to the development and progression of AD, with a focus on identifying new pathways and potential treatments. By utilizing advanced techniques like single-cell RNA sequencing and ATAC sequencing, the study will create detailed models that highlight sex-specific differences in AD pathology. This approach could lead to more personalized diagnostic and therapeutic strategies for individuals affected by Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with the APOE4 allele, and those who may exhibit sex-specific symptoms.
Not a fit: Patients who do not carry the APOE4 allele or who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, tailored treatments for Alzheimer's disease based on a patient's sex and genetic profile.
How similar studies have performed: Other research has shown promising results in understanding the genetic and sex-related factors in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Zhang, Bin — Icahn School of Medicine at Mount Sinai
- Study coordinator: Zhang, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.