Exploring how sepsis affects physical disability in older adults
Understanding pathology of sepsis-induced physical disability for future precision medicine
This study is looking at how sepsis affects older adults over time, especially in terms of physical abilities, and it wants to find out how things like age, gender, and race can influence recovery, so that we can create more personalized ways to help sepsis survivors stay healthy and active.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11121105 on NIH RePORTER |
What this research studies
This research investigates the long-term effects of sepsis on physical disability, particularly in older adults. It aims to understand how factors like age, sex, and race/ethnicity contribute to the variability in recovery outcomes after sepsis. By examining the role of the gut microbiome and other immunologically active organs, the study seeks to develop tailored interventions that can prevent or mitigate physical decline in sepsis survivors. The approach emphasizes precision medicine, moving away from generic treatments to more personalized strategies based on individual patient characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those who have survived sepsis and are experiencing physical disability.
Not a fit: Patients who are younger than 65 years old or those who have not experienced sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that significantly improve recovery and quality of life for sepsis survivors.
How similar studies have performed: While there have been studies on sepsis and recovery, this research's focus on precision medicine and the gut microbiome represents a novel approach that has not been extensively tested.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Mankowski, Robert T — University of Alabama at Birmingham
- Study coordinator: Mankowski, Robert T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.