Exploring how RNA therapy affects fibrinogen's role in blood clotting and inflammation
Official title: Using novel RNA therapy to understand the role of fibrinogen in thromboinflammation in acute and chronic venous thrombosis
Funded at Medical College of Wisconsin · NIH-11033643 · Data updated 2026-11-12
This study is looking at how a protein called fibrinogen affects blood clots and inflammation in people with deep venous thrombosis (DVT), and it aims to find new ways to help treat this condition using a special RNA therapy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $151,523 |
| NIH project number | 1K08HL177422-01 |
| Project ID | NIH-11033643 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for deep venous thrombosis, such as trauma patients or those with chronic inflammatory diseases.
✕Less likely to help
Patients who do not have a history of deep venous thrombosis or related conditions may not benefit from this research.
What this research studies
This research investigates the role of fibrinogen, a key protein in blood clotting, in the context of thromboinflammation associated with deep venous thrombosis (DVT). Using novel RNA therapy, the study aims to understand how fibrinogen contributes to both the formation and resolution of blood clots, particularly in patients with acute and chronic conditions. The research will focus on the cellular mechanisms involved in clot development and the inflammatory response, which could lead to better treatment options for patients suffering from DVT and related complications. By examining these processes, the study hopes to identify new therapeutic targets that could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with deep venous thrombosis, reducing the risk of complications like post-thrombotic syndrome.
How similar studies have gone: While the role of fibrinogen in thromboinflammation has been studied, the use of novel RNA therapy in this context is a relatively new approach that has not been extensively tested.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Dyer, Mitchell R — Medical College of Wisconsin
- Study coordinator: Dyer, Mitchell R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.