Exploring how RNA replicons can boost immune responses against HIV.
Official title: " Investigating the Protective Efficacy of SIV/HIV T and B cell Immunity Induced by RNA Replicons.”
Funded at Massachusetts General Hospital · NIH-11053609 · Data updated 2026-11-12
This study is exploring a new way to boost the immune system's fight against HIV by developing a vaccine that helps your body create strong defenses, and it could lead to better ways to prevent HIV infection for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $865,387 |
| NIH project number | 5R01AI176533-03 |
| Project ID | NIH-11053609 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals at high risk for HIV infection or those interested in preventive strategies against HIV.
✕Less likely to help
Patients who are already living with HIV or those who do not have a risk of HIV exposure may not receive direct benefits from this research.
What this research studies
This research investigates the potential of RNA replicons to enhance the immune system's ability to fight HIV by generating strong T and B cell responses. The approach involves using advanced techniques to identify protective immune responses and developing a vaccine that combines these findings with innovative delivery methods. By leveraging a unique adenoviral vector and lipid-nanoparticle encapsulated mRNA, the study aims to create a vaccine that can effectively stimulate both cellular and antibody-mediated immunity against HIV. Patients may benefit from insights gained in this research that could lead to more effective preventive measures against HIV infection.
Why it matters
Potential benefit: If successful, this research could lead to the development of a more effective prophylactic vaccine against HIV.
How similar studies have gone: Previous research has shown promise in using similar approaches to enhance immune responses against HIV, indicating potential for success in this study.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Gaiha, Gaurav Das — Massachusetts General Hospital
- Study coordinator: Gaiha, Gaurav Das
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.