Exploring how RNA Polymerase III affects the development of facial structures from neural crest cells
Understanding RNA Polymerase III transcription in neural crest cell and craniofacial development
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-11067822
This study is looking at how a specific protein affects the growth of facial structures in babies, especially in cases like Treacher Collins syndrome, by using zebrafish to see what happens when certain genes don’t work right.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11067822 on ClinicalTrials.gov |
What this research studies
This research investigates the role of RNA Polymerase III in the development of craniofacial structures, focusing on neural crest cells (NCC) which are crucial for forming bones and cartilage in the face. By studying zebrafish models, the research aims to understand how disruptions in RNA transcription can lead to craniofacial birth defects, such as Treacher Collins syndrome. The approach includes examining the effects of specific gene mutations on NCC development and the overall impact on craniofacial anomalies. This work could lead to new insights into preventing these birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with craniofacial anomalies, particularly those associated with genetic conditions like Treacher Collins syndrome.
Not a fit: Patients without craniofacial anomalies or those not affected by genetic conditions related to neural crest cell development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new strategies for preventing craniofacial birth defects in infants.
How similar studies have performed: Previous research has shown success in understanding the genetic basis of craniofacial anomalies, indicating that this approach has potential for meaningful insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WATT, KRISTIN EMILY NOACK — UNIVERSITY OF COLORADO DENVER
- Study coordinator: WATT, KRISTIN EMILY NOACK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Berry syndrome, Berry-Treacher Collins syndrome