Exploring how RNA modifications affect cancer-related processes in cells
Official title: Uncovering the Role of RNA Modifications in the Paraspeckle
Funded at Yale University · NIH-10975351 · Data updated 2026-11-12
This study is looking at how tiny changes in RNA, a molecule important for gene expression, can affect a specific part of our cells related to cancer, and it focuses on a particular RNA linked to cancer to help find new ways to treat the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 5F31CA281173-02 |
| Project ID | NIH-10975351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that may be influenced by RNA modifications, particularly those involving the NEAT1 lncRNA.
✕Less likely to help
Patients with cancers unrelated to RNA modifications or those not expressing NEAT1 may not benefit from this research.
What this research studies
This research investigates the role of RNA modifications in regulating the structure and stability of RNA molecules, particularly focusing on a specific cellular structure called the paraspeckle. By using advanced techniques like mass spectrometry and sequencing, the study aims to uncover how these modifications influence the expression of genes involved in cancer. The research will specifically analyze the lncRNA NEAT1, which is linked to cancer, to understand how its modifications may affect cancer progression. This work seeks to provide insights that could lead to the development of targeted cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer treatment by targeting RNA modifications.
How similar studies have gone: While the exploration of RNA modifications is a growing field, this specific focus on paraspeckles and NEAT1 is relatively novel and has not been extensively tested in prior research.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Wilson, Lauren — Yale University
- Study coordinator: Wilson, Lauren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.