Exploring how RNA interacts with proteins in the body
Official title: Chemical Biology Approaches for Investigating RNA-Protein Interactions
Funded at University of Michigan at Ann Arbor · NIH-10840169 · Data updated 2026-11-12
This study is looking at how RNA and certain proteins that bind to it work together, and how problems with these interactions might cause diseases like cancer and brain disorders, with the hope of finding new treatments that could help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $542,079 |
| NIH project number | 1R35GM153185-01 |
| Project ID | NIH-10840169 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancers or neurodegenerative diseases linked to RNA-protein interaction disruptions.
✕Less likely to help
Patients with conditions unrelated to RNA-protein interactions may not benefit from this research.
What this research studies
This research investigates the interactions between RNA and RNA-binding proteins (RBPs), which are crucial for various biological processes such as RNA processing and stability. By developing advanced assays, the project aims to understand how disruptions in these interactions can lead to diseases, including cancers and neurodegenerative conditions. The research will utilize innovative techniques to identify and validate these interactions, potentially leading to new therapeutic strategies targeting RBPs. Patients may benefit from insights gained that could inform the development of RNA-targeted drugs.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by disrupted RNA-protein interactions.
How similar studies have gone: Previous research has shown promise in targeting RNA-protein interactions for therapeutic purposes, indicating a potential for success in this area.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Garner, Amanda — University of Michigan at Ann Arbor
- Study coordinator: Garner, Amanda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.