Exploring how RNA and proteins interact in living cells to develop new drug targeting methods
Official title: Developing RNP-MaP into a broad-spectrum toolset for discovery, definition, and drug targeting of RNA-protein complexes in live cells
Funded at University of Michigan at Ann Arbor · NIH-10940606 · Data updated 2026-11-12
This study is exploring how RNA and proteins that bind to it work together in our cells, with the goal of creating new tools to better understand these interactions, which could help develop better treatments for diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 21, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $313,520 |
| NIH project number | 1R01GM155542-01 |
| Project ID | NIH-10940606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diseases or conditions influenced by RNA-protein interactions, such as certain cancers or genetic disorders.
✕Less likely to help
Patients whose conditions are unrelated to RNA-protein interactions may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between RNA and RNA-binding proteins, which play crucial roles in various biological processes and diseases. The team aims to develop innovative technologies that allow for the mapping and targeting of these RNA-protein complexes within live cells. By utilizing a novel approach called RNP-MaP, they will create methods to identify and analyze the networks formed by these interactions, potentially leading to new therapeutic strategies. Patients may benefit from advancements in drug targeting that arise from a better understanding of these complex interactions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that more effectively target diseases linked to RNA-protein interactions.
How similar studies have gone: Other research has shown promise in targeting RNA-protein interactions, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Weidmann, Chase a — University of Michigan at Ann Arbor
- Study coordinator: Weidmann, Chase a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.