Exploring how rare genetic variations affect brain structure and mental health risks.
Official title: Understanding Rare Genetic Variation and Disease Risk: A Global Neurogenetics Initiative
Funded at Sainte-Justine University Hospital Ctr · NIH-11080342 · Data updated 2026-11-12
This study is looking at how certain genetic changes might affect brain development and behavior in people with neurodevelopmental psychiatric disorders, and it's for anyone interested in understanding the links between genetics and mental health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sainte-Justine University Hospital Ctr NIH-funded |
| Lab location | 1 site (Montreal, Canada) |
| Project start | June 7, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $521,182 |
| NIH project number | 5R01MH129858-03 |
| Project ID | NIH-11080342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with neurodevelopmental psychiatric disorders, particularly those with identified copy number variants.
✕Less likely to help
Patients without neurodevelopmental psychiatric disorders or those without identifiable genetic variations may not benefit from this research.
What this research studies
This research investigates the impact of copy number variants (CNVs) on neurodevelopmental psychiatric disorders by analyzing a large dataset of neuroimaging and genetic information. The study aims to understand how these genetic variations influence brain architecture and function, as well as the behavioral features associated with them. By collaborating across multiple sites in the USA, Canada, and Norway, the research will utilize advanced imaging techniques and statistical models to uncover the relationships between genetic variations and mental health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals with neurodevelopmental psychiatric disorders.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on brain structure and function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sainte-Justine University Hospital Ctr
Montreal, Canada Active
Researchers
- Principal investigator: Jacquemont, Sebastien — Sainte-Justine University Hospital Ctr
- Study coordinator: Jacquemont, Sebastien
Related research
Other NIH-funded projects on the same topics.
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Understanding how rare genetic changes affect brain and risk for neurodevelopmental disorders
A large study will look at people with specific rare genetic changes to see how these affect brain structure, brain activity, and behavior, with the goal of linking genetic variants to ADHD, autism, and other brain disorders.
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Understanding Rare Genetic Variations and Brain Health Across ADHD and Autism
Researchers will study how rare genetic changes affect brain structure and function in people with neurodevelopmental conditions like ADHD and autism, using a large international dataset.
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Understanding how genetic variations affect behavior in neuropsychiatric disorders.
This study is looking at how certain genetic changes might affect behaviors related to mental health issues like anxiety and attention disorders, and it's designed for people with known genetic conditions to help us better understand the link between genes and mental health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.