Exploring how R-loops form and affect genome stability in mammals
Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals
This study is looking at R-loops, which are special structures that can form when DNA is turned into RNA, to see how they can sometimes help and sometimes hurt our genes, especially in relation to certain health issues, using human cells to learn more about how problems with RNA processing can lead to harmful R-loops.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11001108 on NIH RePORTER |
What this research studies
This research investigates the formation of R-loops, which are structures that can occur during the transcription of DNA into RNA. By studying these structures, the research aims to understand the difference between beneficial and harmful R-loops, particularly how they contribute to genome instability and various human disorders. The approach involves using human cellular models to analyze how disruptions in RNA processing can lead to harmful R-loop formation. This could provide insights into the underlying mechanisms of certain genetic conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders associated with RNA processing dysfunction or genome instability.
Not a fit: Patients without any known genetic disorders or those not affected by RNA processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating genetic disorders linked to R-loop formation.
How similar studies have performed: Previous research has shown that understanding R-loop dynamics can lead to significant advancements in genetic disorder treatment, indicating potential success for this approach.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Chedin, Frederic Louis — University of California at Davis
- Study coordinator: Chedin, Frederic Louis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.