Exploring how proteins interact in cells to understand diseases better
Official title: Integrated mass spectrometry-based chemoproteomic and genomic technologies for studying dynamic kinase interactomes
Funded at University of Utah · NIH-11065534 · Data updated 2026-11-12
This study is looking at how proteins and DNA work together in our cells, which is important for understanding diseases like cancer and how they can become resistant to treatments, so that new drug targets and treatment strategies can be developed to help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $385,000 |
| NIH project number | 5R35GM150766-03 |
| Project ID | NIH-11065534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to dysregulated protein interactions, such as cancer or other diseases involving cellular signaling pathways.
✕Less likely to help
Patients with stable conditions that do not involve significant changes in protein interactions may not benefit from this research.
What this research studies
This research investigates the dynamic interactions between proteins and DNA in cells, which are crucial for understanding how diseases like cancer progress and develop resistance to treatments. By using advanced mass spectrometry and chemoproteomic techniques, the study aims to map these interactions in real-time, providing insights into the underlying mechanisms of various diseases. The approach focuses on protein kinases, which play a key role in regulating these interactions and are often targeted by drugs. Patients may benefit from the identification of new drug targets and therapeutic strategies based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that more effectively target diseases by understanding their molecular mechanisms.
How similar studies have gone: Other research has shown success in using mass spectrometry and chemoproteomics to study protein interactions, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Golkowski, Martin — University of Utah
- Study coordinator: Golkowski, Martin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.