Exploring how protein behavior changes with age and affects diseases
Investigating protein phase separation and aggregation in age dependent human disease
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10859986
This study is looking at how proteins in our bodies change as we get older, which might help explain why some age-related diseases happen, and it's for anyone interested in understanding how these changes could affect their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10859986 on ClinicalTrials.gov |
What this research studies
This research investigates how proteins can change their organization and behavior as people age, potentially leading to diseases. It focuses on a phenomenon called protein phase separation, where proteins can clump together to form distinct compartments within cells. By studying various human disease-related proteins and their mutations, the research aims to understand how these changes contribute to the onset and progression of age-related diseases. The approach combines advanced techniques in biochemistry, cell biology, and physiological modeling to uncover the links between protein behavior and human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related diseases or those with genetic mutations linked to such conditions.
Not a fit: Patients with acute, non-age-related diseases or those without genetic mutations associated with aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of age-related diseases and inform the development of targeted therapies.
How similar studies have performed: Previous research has shown promising results in understanding protein behavior in relation to diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAROSZ, DANIEL — STANFORD UNIVERSITY
- Study coordinator: JAROSZ, DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.