Exploring how protein behavior changes with age and affects diseases
Official title: Investigating protein phase separation and aggregation in age dependent human disease
Funded at Stanford University · NIH-10859986 · Data updated 2026-11-12
This study is looking at how proteins in our bodies change as we get older, which might help explain why some age-related diseases happen, and it's for anyone interested in understanding how these changes could affect their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 30, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $780,644 |
| NIH project number | 1R01AG086495-01 |
| Project ID | NIH-10859986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related diseases or those with genetic mutations linked to such conditions.
✕Less likely to help
Patients with acute, non-age-related diseases or those without genetic mutations associated with aging may not benefit from this research.
What this research studies
This research investigates how proteins can change their organization and behavior as people age, potentially leading to diseases. It focuses on a phenomenon called protein phase separation, where proteins can clump together to form distinct compartments within cells. By studying various human disease-related proteins and their mutations, the research aims to understand how these changes contribute to the onset and progression of age-related diseases. The approach combines advanced techniques in biochemistry, cell biology, and physiological modeling to uncover the links between protein behavior and human health.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of age-related diseases and inform the development of targeted therapies.
How similar studies have gone: Previous research has shown promising results in understanding protein behavior in relation to diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Jarosz, Daniel — Stanford University
- Study coordinator: Jarosz, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.