Exploring how pregnancy complications may lead to Alzheimer's disease.
Official title: Investigating Pathways from Adverse Pregnancy Outcomes to Alzheimer's Disease and Related Dementias: the nuMoM2b-Brain Study
Funded at University of Pittsburgh at Pittsburgh · NIH-11329452 · Data updated 2026-11-12
This study is looking at how problems during pregnancy, like having a preterm baby or high blood pressure, might affect a mother's chances of developing Alzheimer's or other memory issues later on, and it’s for moms who have experienced these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,806,846 |
| NIH project number | 7R01AG085475-02 |
| Project ID | NIH-11329452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who had adverse pregnancy outcomes and are currently in the follow-up phase of the nuMoM2b study.
✕Less likely to help
Patients who did not experience any pregnancy complications or who are not part of the nuMoM2b cohort may not benefit from this research.
What this research studies
This research investigates the connection between adverse pregnancy outcomes, such as preterm birth and hypertensive disorders, and the risk of developing Alzheimer's disease and related dementias later in life. By utilizing a diverse cohort of mothers who experienced these complications, the study aims to understand the biological mechanisms that may link pregnancy issues to cognitive decline. Participants will be followed over several years to gather detailed health data and neurocognitive assessments, providing insights into how these early life events may influence long-term brain health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing Alzheimer's disease in women who have experienced adverse pregnancy outcomes.
How similar studies have gone: While the specific pathways being investigated are novel, previous research has shown that pregnancy complications can impact long-term health, suggesting potential for meaningful findings.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Miller, Eliza C — University of Pittsburgh at Pittsburgh
- Study coordinator: Miller, Eliza C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.