Exploring how prebiotic diets affect immune responses and bone health during estrogen deficiency
Official title: Mathematical Modeling of the Impacts of Prebiotic Dietary Intervention on Immunomodulation During Estrogen Deficiency
Funded at State University of New York at Buffalo · NIH-10828927 · Data updated 2026-11-12
This study is looking at how certain dietary fibers called prebiotics might help boost the immune system and support bone health in postmenopausal women, especially those dealing with osteoporosis, to see if these foods can lead to better health outcomes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | April 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $239,582 |
| NIH project number | 5R21AG077640-02 |
| Project ID | NIH-10828927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postmenopausal women experiencing bone health issues related to estrogen deficiency.
✕Less likely to help
Patients who are not postmenopausal or do not have bone health concerns related to estrogen deficiency may not benefit from this research.
What this research studies
This research investigates the effects of prebiotic dietary interventions on immune responses and bone health in the context of estrogen deficiency, particularly in postmenopausal women. By utilizing mathematical modeling alongside in vivo animal studies, the project aims to understand how prebiotics like B-galactooligosaccharides can influence immune cell behavior and bone maintenance. The study focuses on the interactions between gut microbiota, immune cells, and bone health, providing insights into potential dietary strategies for improving outcomes in osteoporosis. Patients may benefit from findings that could lead to new dietary recommendations or treatments for bone health.
Why it matters
Potential benefit: If successful, this research could lead to innovative dietary interventions that improve bone health and immune function in postmenopausal women.
How similar studies have gone: Previous research has shown promising results in using dietary interventions to influence gut health and immune responses, suggesting potential success for this approach.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Ford Versypt, Ashlee Nicole — State University of New York at Buffalo
- Study coordinator: Ford Versypt, Ashlee Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.