Exploring how patients with cirrhosis make decisions about surgery
Official title: Understanding Patient Preferences for Surgical Management in the Setting of Cirrhosis: A Mixed-Methods Approach
Funded at University of Pennsylvania · NIH-11055296 · Data updated 2026-11-12
This study is looking at what patients with cirrhosis think about surgery for abdominal hernias, so we can better understand their choices and help them make informed decisions with their doctors, ultimately aiming to improve their satisfaction and quality of life.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $121,875 |
| NIH project number | 5R03DK134794-02 |
| Project ID | NIH-11055296 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with cirrhosis who are considering or have been recommended for surgical procedures.
✕Less likely to help
Patients without cirrhosis or those not facing surgical decisions may not benefit from this research.
What this research studies
This research investigates the preferences and decision-making processes of patients with cirrhosis regarding surgical management, particularly in the context of abdominal hernias. By using a mixed-methods approach, the study aims to gather qualitative data from diverse patients to understand their perspectives on surgical risks and outcomes. The goal is to enhance shared decision-making between patients and healthcare providers by incorporating patient-important outcomes into discussions about surgery. This could lead to improved satisfaction and quality of life for patients undergoing surgical procedures.
Why it matters
Potential benefit: If successful, this research could lead to more informed and personalized surgical decisions for patients with cirrhosis, ultimately improving their satisfaction and outcomes.
How similar studies have gone: While there has been research on surgical decision-making in general, this study's focus on the patient perspective in the context of cirrhosis is relatively novel and untested.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Mahmud, Nadim — University of Pennsylvania
- Study coordinator: Mahmud, Nadim
Related research
Other NIH-funded projects on the same topics.
-
Statin therapy for people with compensated cirrhosis
A big, long-term study at a major university is looking at whether statins can help people with compensated cirrhosis live longer and feel better.
-
Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
-
Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
-
Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
-
Cirrhosis Network study to understand mortality and therapies
A large, multi-center study in people with cirrhosis to find better ways to predict deaths and test the potential of statins to prevent complications like liver cancer and liver failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.