Exploring how oxygen levels in tumors affect cancer signaling pathways
Understanding the impact that tumor representative oxygen tension has on phosphotyrosine-dependent signaling networks in solid tumors
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11094071
This study is looking at how different levels of oxygen in tumors affect the way cancer cells grow and spread, with the hope of finding new ways to make treatments more effective for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11094071 on ClinicalTrials.gov |
What this research studies
This research investigates how varying oxygen levels within solid tumors influence the signaling networks that are crucial for tumor growth and spread. By focusing on phosphotyrosine signaling, particularly involving tyrosine kinases, the study aims to uncover how the tumor microenvironment, especially oxygen tension, alters these pathways. The researchers will analyze how these changes can create vulnerabilities in cancer cells that may be targeted for more effective treatments. This work could lead to new strategies for improving patient outcomes in cancer therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors, particularly those who may have metastasized to hypoxic environments like the brain.
Not a fit: Patients with non-solid tumors or those whose cancer is not influenced by phosphotyrosine signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by targeting specific vulnerabilities in tumors based on their oxygen levels.
How similar studies have performed: Previous research has shown that targeting phosphotyrosine signaling networks can be effective in cancer treatment, indicating a promising avenue for this study.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAYRO, BENJAMIN JACOB — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: MAYRO, BENJAMIN JACOB
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.